Work

Regulatory T cells in skeletal muscle repair and regeneration: recent insights

Year: 2022

Type: review

Abstract: Skeletal muscle repair and regeneration after injury is a multi-stage process, involving a dynamic inflammatory microenvironment consisting of a complex network formed by the interaction of immune cells and their secreted cytokines. The homeostasis of the inflammatory microenvironment determines whether skeletal muscle repair tissues will ultimately form scar tissue or regenerative tissue. Regulatory T cells (Tregs) regulate homeostasis within the immune system and self-immune tolerance, and play a crucial role in skeletal muscle repair and regeneration. Dysregulated Tregs function leads to abnormal repair. In this review, we discuss the role and mechanisms of Tregs in skeletal muscle repair and regeneration after injury and provide new strategies for Treg immunotherapy in skeletal muscle diseases.

Source: Cell Death and Disease

DOI: 10.1038/s41419-022-05142-8

Authors: Jianhui Wu, Bowen Ren, Daochao Wang, Hui Lin

Institutions: Nanchang University, Capital Medical University, Beijing Luhe Hospital Affiliated to Capital Medical University, Chinese PLA General Hospital

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,290