Modulatory effects of Porphyra-derived polysaccharides, oligosaccharides and their mixture on antigen-specific immune responses in ovalbumin-sensitized mice
Year: 2022
Type: article
Abstract: Although recent studies indicated the immune modulatory effects of Porphyra extract and derived polysaccharides, the impact of Porphyra-derived oligosaccharides on immune responses remains unclear. This study aimed to explore the influence of Porphyra-derived polysaccharides (PP), oligosaccharides (PO) and the PO/PP mixture on antigen-specific immune responses in ovalbumin (OVA)-sensitized mice. Daily treatment with PP, PO, or PO/PP mixture did not influence the body weight, spleen weight index, serum levels of total and OVA-specific IgG. However, the levels of IgG1, IgG2a, total and OVA-specific IgE were down-regulated. Furthermore, productions of IL-2, IFN-γ, IL-4, and IL17 from splenocytes were diminished in mice treated with PP, PO, and PO/PP mixture. In contrast, the secretion of IL-10 was slightly increased and the ratio of IL-10/IL-4 was markedly raised. These results demonstrated the modulatory effects of PP, PO, and PO/PP mixture on antigen-specific immune responses, revealing their potential to be developed as functional foods for immunomodulation.
Source: Journal of Functional Foods
Institution: National Taiwan Ocean University
Language: English
Subfield: Aquatic Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,160
Awards: G2205640134, Preparation of Porphyra Extract-Containing Nanoemulsions and Evaluation of Their Effects on Ameliorating Candida Albicans Infection, G2561886033, The Study on the Processing Protocol Based on Biorefinery Concept to Produce Pe and Ace Inhibitory Peptides from Porphyra Sp. and Using Seaweed Residues to Output Health Additive of Animal Feed and Make Phenyllactic Acid via Hydrolysis and Lab Fermentation, G737106015, G7656850130, G8985157498
OpenAlex ID: W4290052425