Biomimetic semiconducting polymer dots for highly specific NIR-II fluorescence imaging of glioma
Year: 2022
Type: article
Abstract: Glioma with very short medium survival time consists of 80% of primary malignant types of brain tumors. The unique microenvironment such as the existence of the blood-brain barrier (BBB) makes the glioma theranostics exhibit low sensitivity in diagnosis, a poor prognosis and low treatment efficacy. Therefore, the development of multifunctional nanoplatform that can cross BBB and target the glioma is essential for the high-sensitivity detection and ablation of cancer cells. In this study, C6 cell membrane-coated conjugated polymer dots (Pdots-C6) were constructed for targeted glioma tumor detection. As a new kind of biomimetic and biocompatible nanoprobes, Pdots-C6 preserve the complex biological functions of natural cell membranes while possessing physicochemical properties for NIR-II fluorescence imaging of glioma. After encapsulating C6 cell membrane on the surface of conjugated Pdots, Pdots-C6 exhibited the most favorable specific targeting capabilities in vitro and in vivo. In particular, this pilot study demonstrates that biomimetic nanoparticles offer a potential tool to enhance specific targeting to the brain, hence improving glioma tumor detection accuracy.
Source: Materials Today Bio
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,000
Funders: Natural Science Foundation of Changzhou City, Natural Science Foundation of Guangdong Province, Universidade de Macau, Fundo para o Desenvolvimento das Ciências e da Tecnologia, Science, Technology and Innovation Commission of Shenzhen Municipality, Shenzhen Fundamental Research Program, Shenzhen Bay Laboratory, National Key Research and Development Program of China
Awards: G1028971287, G1037906095, G1142939785, G153949905, G1692762090, G2110635143, G2135021160, G2137137920, G230242097, G2339008934, G2397937129, G2654247948, G2847920216, G3163518713, G322563901, G3400325694, G3401960152, G3764702539, G3777690747, G3808700663, G3841034842, G4008981198, G410204397, G4255113313, G4744198118, G4807235213, G5029724536, G5296922114, G5484156350, G5957709507, G5958703034, G6122826457, G6237013801, G6322163556, G6552393536, G6673724301, G6827062628, G730305595, G7377256091, G7619587477, G77922700, G8022564439, G8042199575, G8151723550, G8268559770, G8573950860, G8967941741, G975338501
OpenAlex ID: W4290237461