Year: 2022
Type: review
Abstract: The procurement and management of nutrients and ability to fight infections are fundamental requirements for survival. These defense responses are bioenergetically costly, requiring the immune system to balance protection against pathogens with the need to maintain metabolic homeostasis. NF-κB transcription factors are central regulators of immunity and inflammation. Over the last two decades, these factors have emerged as a pivotal node coordinating the immune and metabolic systems in physiology and the etiopathogenesis of major threats to human health, including cancer, autoimmunity, chronic inflammation, and others. In this review, we discuss recent advances in understanding how NF-κB-dependent metabolic programs control inflammation, metabolism, and immunity and how improved knowledge of them may lead to better diagnostics and therapeutics for widespread human diseases.
Source: Trends in Immunology
Institutions: University of L'Aquila, Imperial College London
Language: English
Topic: NF-κB Signaling Pathways
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $6,700
Awards: G2445949685, G3534681832, G3601453622, G4108308124, Treating Multiple Myeloma and Diffuse Large B Cell Lymphoma by Targeting the NF-kB Pathway with the First-in-Class GADD45b/MKK7 Inhibitor, DTP3, G4324006831, G5046496225, G5209448701, G6677337009, G7548786943, G7739647646, G8761676649, G8950771732
OpenAlex ID: W4291000418