Work

Towards novel tacrine analogues: Pd(dppf)Cl 2 ·CH 2 Cl 2 catalyzed improved synthesis, in silico docking and hepatotoxicity studies

Year: 2022

Type: article

Abstract: docking studies of the synthesized compounds were carried out against the acetylcholinesterase (AChE) enzyme. The hepatotoxicity studies of these compounds were done against complexes of CYP1A2 and CYP3A4 proteins with known inhibitors like 7,8-benzoflavone and ketoconazole, respectively.

Source: RSC Advances

DOI: 10.1039/d2ra03225b

Authors: Aravinda Babu, Muthipeedika Nibin Joy, K. Sunil, Ayyiliath Meleveetil Sajith, Sougata Santra, Grigory V. Zyryanov, Olga A. Konovalova, Ilya I. Butorin, Keesaram Muniraju

Institutions: Sri Siddhartha Academy of Higher Education, Ural Federal University, Russian Academy of Sciences, Institute of Organic Synthesis, Sri Venkateswara University

Language: English

Topic: Cholinesterase and Neurodegenerative Diseases

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042

Funders: Russian Science Foundation, Ministry of Science and Higher Education of the Russian Federation, Council on grants of the President of the Russian Federation

Awards: G1717111205, G178207014, G2038549030, G245088544, G2822527739, G3665410561, G369089146, G417126629, G6444257319, G6633408731, G8524880525

OpenAlex ID: W4291015271

FWCI: 1.422

Cites: 23

Cited by: 12

Related to: 10