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Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines

Year: 2022
Type: article
Abstract: magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid-polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox desorption from the surface of nanomaterials under the action of an alternating magnetic field (AMF) in acidic and neutral media was evaluated. Their high cytotoxicity against tumor cells, as well as the drug release upon application of AMF, which leads to an increase in the cytotoxic effect, was demonstrated.
DOI: 10.3390/ijms23169093
Authors: Alexander M. Demin, Alexander V. Vakhrushev, Alexandra G. Pershina, Marina S. Valova, Lina V. Efimova, Alexandra A. Syomchina, Mikhail A. Uimin, Artem S. Minin, Galina L. Levit, Victor P. Krasnov, Valery N. Charushin
Institutions: Russian Academy of Sciences, Institute of Organic Synthesis, Siberian State Medical University, Tomsk Polytechnic University, National Research Tomsk State University, M.N. Mikheev Institute of Metal Physics, Ural Federal University
Language: English
Subfield: Biomaterials
Open Access status: gold
Estimated APC paid: $2,408
OpenAlex ID: W4291885437
FWCI: 1.32
Cites: 41
Cited by: 29
Related to: 10