Work

Population Pharmacokinetic Modeling and Simulation of Rifapentine Supports Concomitant Antiretroviral Therapy with Efavirenz and Non-Weight Based Dosing

Year: 2022

Type: article

Abstract: The Brief Rifapentine–Isoniazid Efficacy for TB Prevention/A5279 trial demonstrated a 1-month daily regimen of rifapentine and isoniazid was noninferior to 9 months of isoniazid alone for preventing TB in persons living with HIV (PLWH). Our objective was to evaluate rifapentine pharmacokinetics in trial participants receiving antiretroviral therapy (ART) and perform simulations to compare weight-based rifapentine dosing with a standard, fixed dose.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02385-21

Authors: Michelle M. Pham, Anthony T. Podany, Noluthando Mwelase, Khuanchai Supparatpinyo, Lerato Mohapi, Amita Gupta, Wadzanai Samaneka, Ayotunde Omoz-Oarhe, Deborah Langat, Constance A. Benson, Richard E. Chaisson, Susan Swindells, Courtney V. Fletcher

Institutions: University of Nebraska Medical Center, University of the Witwatersrand, Chiang Mai University, Perinatal HIV Research Unit, Johns Hopkins Hospital, Kenya Medical Research Institute, University of California San Diego, Johns Hopkins University

Language: English

Topic: Antibiotics Pharmacokinetics and Efficacy

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases

Awards: AIDS Clinical Trials Group Network, Clinical Pharmacology of Efavirenz Combined with High Dose Rifapentine, UZ-UCSF Clinical Trials Unit, UZ-UCSF CTU, UCSD Collaborative Clinical Trials Unit, Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections, Botswana-Harvard T.H. Chan School of Public Health AIDS Initiative Partnership CTU, AIDS Clinical Trial Group Laboratory Center, Statistical and Data Management Center (SDMC), Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (ACTG), Johns Hopkins University Baltimore India Clinical Trail Unit (JHUBI CTU), University of North Carolina Global HIV Prevention and Treatment Clinical Trials Unit, Thailand HIV/AIDS and Infectious Disease Clinical Trials Unit (THAI CTU), Wits HIV Research Group CLINICAL TRIAL UNIT (CTU) reapplication, PHRU-Setshaba Clinical Trials Unit

OpenAlex ID: W4292401005

FWCI: 0.646

Cites: 16

Cited by: 5

Related to: 10