Three-step Synthesis of Various-1h-1,2,3-triazol-4- Yl) Methyl) Pyrido[2,3-b]pyrazin-2(1h)-ones Via C-n Junction and Their Anti-proliferative Activity
Year: 2022
Type: article
Abstract: Herein, we depict the reaction subbed with a blending bar originate the alkyne (III) and azide was added CuSO4/sodium ascorbate of 1.2 eq K2CO3 and the response combination was mixed at RT for 16-18 h. After work up to bear the preferred 1-((1-aryl) - 1H-1,2,3-triazol-4-yl) methyl) quinoxalin-2(1H)- ones (IV a-IV j) item. This large number of mixtures were evaluated for their hostile to disease action against human malignant growth cell lines by means of MCF-7,A-549 and HeLa. In vitro against malignant growth movement uncovers that a couple of mixtures displayed strong inhibitory in an assortment of disease cell lines. Among them 1-((1-(2,4- dimethoxyphenyl)- 1H-1,2,3-triazol-4-yl)methyl)pyrido[2,3-b]pyrazin-2(1H)- one (IV j) with 2,4-OCH3C6H3 MCF7 (3.64 ± 0.92), HeLa (4.62 ± 0.29), A-549 (8.02 ± 0.94) promising enemy of multiply movement .1-((1-(4- nitrophenyl)- 1H-1,2,3-triazol-4-yl)methyl)pyrido[2,3-b]pyrazin-2(1H)- one(IVi) with p-NO2C6H4 MCF-7 (4.15 ± 1.02), HeLa (6.43 ± 1.67), A-549 (10.74 ± 1.88) potent.1-((1-(2,4-dichlorophenyl)- 1H-1,2,3-triazol-4- yl)methyl)pyrido[2,3-b]pyrazin-2(1H)- one (IV h) with 2,4-ClC6H3 MCF-7 (5.02 ± 1.38), HeLa (8.84 ± 2.01), A-549 (12.18 ± 2.82) great action. Etoposide utilized as a positive control.
Source: RASAYAN Journal of Chemistry
Authors: Pavani V, Jagadeesh Kumar Ega
Institution: Chaitanya
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4293209130