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Ribosome-Directed Therapies in Cancer

Year: 2022
Type: review
Abstract: The human ribosomes are the cellular machines that participate in protein synthesis, which is deeply affected during cancer transformation by different oncoproteins and is shown to provide cancer cell proliferation and therefore biomass. Cancer diseases are associated with an increase in ribosome biogenesis and mutation of ribosomal proteins. The ribosome represents an attractive anti-cancer therapy target and several strategies are used to identify specific drugs. Here we review the role of different drugs that may decrease ribosome biogenesis and cancer cell proliferation.
Source: Biomedicines
DOI: 10.3390/biomedicines10092088
Authors: Gazmend Temaj, Silvia Chichiarelli, Margherita Eufemi, Fabio Altieri, Rifat Hadziselimovic, Ammad Ahmad Farooqi, Ilhan Yaylim, Luciano Saso
Institutions: University for Business and Technology, Sapienza University of Rome, University of Sarajevo, Institute of Biomedical and Genetic Engineering, Istanbul University, Istituto Superiore di Sanità
Language: English
Open Access status: gold
Estimated APC paid: $2,303
OpenAlex ID: W4293414971
FWCI: 0.857
Cites: 222
Cited by: 41
Related to: 10