Culcitiolides E–J, Six New Eremophilane-Type Sesquiterpene Derivatives from Senecio culcitioides
Year: 2013
Type: article
Abstract: Culcitiolides E–J (1–6), six new eremophilane-type sesquiterpenes, were isolated from the stem of Senecio culcitioides SCH. BIP. (Asteraceae). The structures were determined by detailed NMR spectral analysis. The inhibitory activities of these compounds against nuclear factor κB (NF-κB)-dependent gene expression were assessed. Culcitiolides E, H, and I potently inhibited NF-κB-induced gene expression at 20 µM.
Authors: Taichi Mitsui, Ken-ichiro Hayashi, Mikiko Kawai, Masahiro Kido, Hiroyuki Tani, Daisuke Takaoka, Nobuyasu Matsuura, Hiroshi Nozaki
Institutions: Okayama University of Science, Ehime University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4293748657