Work

Genetic study of I kappa B alpha gene promoter polymorphism associated with hepatitis C virus in Egyptian patients

Year: 2022

Type: article

Abstract: Background: Host genetic polymorphism is one of the major unalterable major factors for HCV infection, NF-κB proteins play multiple roles in immune response and involve in HCV infection and progression. Aim of the study: To investigate the associations between single nucleotide polymorphism (SNPs) in NF-Kb and the susceptibility as well as resolution of HCV infection. Patients and Methods: This prospective case-control study was conducted at the physical examination center on 150 Egyptian population, including 50 uninfected control cases, 50 cases with spontaneous viral clearance, and 50 cases with persistent HCV infection, they are genotyped for four SNPs (rs11820062, rs230530, rs1056890 and rs3774963) using a Taq Man assay. Results: The current study revealed that the mutation in rs_11820062 of the I kappa B alpha gene significantly increased the risk for HCV infection with a p-value <0.05. Conclusion: This study revealed that genetic variants of the NF-κB pathway genes (rs11820062 T allele) are associated with an increased risk of HCV susceptibility.

Source: Journal of Bioscience and Applied Research/Journal of Bioscience and Applied Research

DOI: 10.21608/jbaar.2022.255496

Authors: Mamoun Ghazalah, Sameer El-Masry, Ibrahim Helmy, Ehab Abd-Elkhalek

Institutions: University of Sadat City, Kafrelsheikh University, Mansoura University

Language: English

Topic: Hepatitis C virus research

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $120