Avaliação do perfil clínico-epidemiológico dos óbitos por COVID-19 em homens e mulheres adultos no estado do Maranhão
Year: 2022
Type: article
Study design: Observational Study
Abstract: The severe acute respiratory syndrome coronavirus (SARS-CoV-2) has spread worldwide and caused Coronavirus Disease 2019 (COVID-19) in approximately 46 million people by November 2020, configuring a pandemic after an alert from the World Health Organization. The most prevalent comorbidities of patients infected with SARS-CoV-2 are systemic arterial hypertension and diabetes mellitus. Such patients who frequently undergo treatment with angiotensin-converting enzyme 2 inhibitors or angiotensin II type I receptor blockers have a considerable increase in the expression of angiotensin-converting enzyme 2 (ACE2) receptors, facilitating the entry of the coronavirus. These same patients end up developing a worse prognosis of the pathology, which can be lethal. Other studies have shown that adult women and men respond differently to SARS-CoV-2 infection. The expression of ACE2 is influenced by sex hormones, thus, it would be one of the reasons for the higher male prevalence. In Maranhão, cases of infection were initially investigated at the end of February, with two suspects. Regarding mortality, males had a higher rate (62%), which shows the relevance of gender in the prognosis. The present research intends to analyze, through a data collection, the clinical-epidemiological profile of deaths by COVID-19 in adult men and women in the state of Maranhão, establishing a comparison between the symptoms of COVID-19, considering not only the epidemiological profile, as well as the sociodemographic profile and associated morbidities, in addition to discussing the incidence of forms of severity of the disease in both sexes.
Source: E-Acadêmica
Authors: Gustavo Soares Gomes Barros Fonseca, Rodrigo Sevilla Noleto, Luciana Martinuzzi Breitenbach, Heloisa Silva Leal, Maria Eduarda de Carvalho Penha Carneiro, Lindomar Faria de Freitas Júnior, Felipe Teixeira Costa, Ana Emanuelle Ribeiro Nunes Carvalho, Fabricia Carvalho Dourado Pereira, Victor Matheus Santos da Silva, Maria Luiza Tenório Dantas Britto, Yasmin de Matos Capistranio, Priscilla Leite Cordeiro, Myrela Murad Sampaio, Lorena Cristina Lima Barbosa, Larissa Lima Vieira, Amanda Karen de Oliveira Freitas, Edduardo Willker Teixeira de Rezende, Maria Tenório Dantas Britto, Lohanne de Lima Brustolon, José Elias Moreira Gomes, Gabriella Rodrigues Araujo, Victor de Castro Araujo, Marco Antonio Leite, Jusciellyson da Silva Nava, Ianca Thais Lopes Marques
Language: Portuguese
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4294315134