Work

Roles of the functional domains and conserved residues of the severe fever with thrombocytopenia syndrome virus L protein provide insights into the viral RNA transcription/replication mechanism

Year: 2022

Type: article

Abstract: • All the domains of SFTSV-L protein were required for its function in viral RNA replication/transcription. • The influence of twelve conserved residues were evaluated, nine of which showed significance in the function of L protein. • Nine residues of SFTSV-L were strictly conserved among phleboviruses, suggesting its potency as a promising drug target.

Source: Virologica Sinica

DOI: 10.1016/j.virs.2022.08.009