Front Cover: Eleven‐Residue Peptaibols Isolated from Trichoderma longibrachiatum Rifai DMG‐3‐1‐1and Their Structure‐Activity Relationship (Chem. Biodiversity 9/2022)
Year: 2022
Type: paratext
Abstract: Front Cover. Total 23 eleven-residue peptaibols, including five reported ones (1–5) in our previous work, were isolated from the fungus Trichoderma longibrachiatum Rifai DMG-3-1-1, which was obtained from the mushroom Clitocybe nebularis. The structures of the 13 new peptaibols (6–10 and 12–19) were determined by their NMR, MALDI-MS/MS, ECD data and Marfey's analyses. Comparison of the IC50s against the tested cell lines indicated that the 2nd (Gln2/Asn2), 3rd (Ile3/Val3) and 4th (Ile4/Val4) amino acid residues affected their cytotoxicities powerfully. Compounds 2, 5, 9, 11, 21 and 22 also showed moderate antibacterial activities against Staphylococcus aureus MRSA T144. This article analyzed the structure-activity relationship of eleven-residue peptaibols comprehensively, and further enriched the family of peptaibol, as reported by Zhang et al. in their research article at 10.1002/cbdv.202200627.
Source: Chemistry & Biodiversity
Authors: Shu‐Hua Zhang, Xue Zhao, Rui Xu, Yu Yang, Jing Tang, Xian‐Lin Yue, Yu‐Ting Wang, Hong‐Yu Tan, Guo‐Gang Zhang, Chang‐Wei Li
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4295338728