Relationship between protein arginine methyltransferase and cardiovascular disease (Review)
Year: 2022
Type: review
Abstract: Protein arginine methyltransferases (PRMTs) are widely found in eukaryotes and regulate gene expression and post-translational modifications. PRMT1-PRMT6 have important roles in the pathology of cardiovascular diseases (CVDs), including atherosclerosis, heart failure and myocardial hypertrophy. Although these enzymes are also closely associated with various CVDs, the mechanisms of the involvement of PRMTs in the regulation of CVD have remained largely elusive. PRMTs methylate arginine residues and other factors. The present review describes the roles of PRMT1-PRMT6 in CVD. Furthermore, the biological characteristics of PRMTs and mechanisms by which PRMTs regulate cholesterol metabolism are being introduced. This review aims to provide inspiration for cardiovascular drug research and offer clues for research on the pathogenesis of CVD.
Source: Biomedical Reports
DOI: 10.3892/br.2022.1572
Authors: Sisi Zheng, Congcong Zeng, Ailing Huang, Fuqi Huang, Anna Meng, Zhuan Wu, Shouhong Zhou
Institution: Guilin Medical University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
Awards: G2270739431, G4546095801
OpenAlex ID: W4296281159