Impact of Sulfur Fumigation on Ginger: Chemical and Biological Evidence
Year: 2022
Type: article
Abstract: We previously found that sulfur fumigation, a commonly used controversial method for the post-harvest handling of ginger, induces the generation of a compound in ginger, which was speculated to be a sulfur-containing derivative of 6-shogaol based on its mass data. However, the chemical and biological properties of the compound remain unknown. As a follow-up study, here we report the chemical structure, systemic exposure, and anticancer activity of the compound. Chromatographic separation, nuclear magnetic resonance analysis, and chemical synthesis structurally elucidated the compound as 6-gingesulfonic acid. Pharmacokinetics in rats found that 6-gingesulfonic acid was more slowly absorbed and eliminated, with more prototypes existing in the blood than 6-shogaol. Metabolism profiling indicated that the two compounds produced qualitatively and quantitatively different metabolites. It was further found that 6-gingesulfonic acid exerted significantly weaker antiproliferative activity on tumor cells than 6-shogaol. The data provide chemical and biological evidence that sulfur fumigation may impair the healthcare functions of ginger.
Authors: Wei-Hao Zhang, Han-Yan Luo, Jing Fang, Chen-Liang Zhao, Kam-Chun Chan, Yui-Man Chan, Cai-Xia Dong, Hu-Biao Chen, Zhong-Zhen Zhao, Song-Lin Li, Jun Xu
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,000
Awards: A reliable method for inspecting sulfur-fumigated Chinese medicinal materials, Investigating the scientific basis behind the ancient processing method of heshouwu by hepatotoxicity assessment and chemical characterization, Exploring the glycosyl structural specificity of multiple components involved in the gut microbiota-targeted anti-obesity effect of ginseng, A reliable method for inspecting sulfur-fumigated Chinese medicinal materials, G6002165927
OpenAlex ID: W4296986540