Multifunctional Gold Nanoclusters for Effective Targeting, Near-Infrared Fluorescence Imaging, Diagnosis, and Treatment of Cancer Lymphatic Metastasis
Year: 2022
Type: article
Abstract: are different functional thiol ligands)-type GNCs, which display highly effective LN targeting, excellent stability and biocompatibility, and optimal body-retention time. Moreover, they can provide continuous NIR fluorescence imaging of LNs for >3 h from a single dose, making them well-suited for fluorescence-guided surgery. Importantly, we have further incorporated methotrexate, a chemotherapeutic drug, into the GNCs without affecting their LN-targeting ability. Consequently, they can significantly improve the efficiency of methotrexate delivery to target LNs, achieving excellent therapeutic efficacy with up to 4-fold lower hepatotoxicity. Thus, the GNCs are highly effective and safe theranostic nanomedicines against cancer lymphatic metastasis.
Source: ACS Nano
Authors: Zeyang Pang, Weixiao Yan, Jie Yang, Qizhen Li, Yuan Guo, Dejian Zhou, Xingyu Jiang
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $5,000
Funders: Royal Society, National Natural Science Foundation of China, Chinese Academy of Sciences, Ministry of Science and Technology of the People's Republic of China, Science, Technology and Innovation Commission of Shenzhen Municipality, Southern University of Science and Technology, Shenzhen Bay Laboratory, Directorate for Biological Sciences, Biotechnology and Biological Sciences Research Council, Suzhou Institute of Nanotechnology, Chinese Academy of Sciences
OpenAlex ID: W4297876569