Work

Elevated risk of thrombotic manifestations of SARS-CoV-2 infection in cancer patients: A literature review

Year: 2022

Type: article

Abstract: Coronavirus disease 2019 (COVID-19) results in higher risks of hospitalization or death in older patients and those with multiple comorbidities, including malignancies. Patients with cancer have greater risks of COVID-19 onset and worse prognosis. This excess is mainly explained by thrombotic complications. Indeed, an imbalance in the equilibrium between clot formation and bleeding, increased activation of coagulation, and endothelial dysfunction characterize both COVID-19 patients and those with cancer. With this review, we provide a summary of the pathological mechanisms of coagulation and thrombotic manifestations in these patients and discuss the possible therapeutic implications of these phenomena.

Source: EXCLI journal

DOI: 10.17179/excli2022-5073

Authors: Annunziata Stefanile, Maria Cellerino, Tatiana Koudriavtseva

Institutions: Istituti Fisioterapici Ospitalieri, Instituto Nazionale Tumori Regina Elena, University of Genoa

Language: English

Topic: COVID-19 Clinical Research Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4298087643

FWCI: 0.126

Cites: 81

Cited by: 1

Related to: 10