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THE PROTECTIVE EFFECT OF 17β-ESTRADIOL DERIVATIVE — PE0607 ON THE METABOLIC SYNDROME MANIFESTATION IN OVARIECTOMIZED RATS WITH HYPOTHYROIDISM

Year: 2012

Type: article

Abstract: The protective effect of compound PE0607 on the metabolic syndrome manifestation induced by high-calorie diet with thyreostatic was investigated in the rats with estrogen deficiency. It was established that PE0607 administrations delayed the development of insulin resistance, improved glucose intolerance, decreased visceral fat weights and hypertriglycerides, promotes the products of nitric oxide. In addition, uterine weight was not affected by compound PE0607. The revealed selective effect of compound PE0607 on major factors of cardiometabolic risk justify the perspectives as potential cardioprotective agent for the treatment of metabolic syndrome in postmenopausal women with hypothyroidism.

Source: PROBLEMS OF ENDOCRINE PATHOLOGY

DOI: 10.21856/j-pep.2012.1.07

Authors: Nataliia Gorbenko, K. V. Taran, Oleksii Borikov, Olha Ivanova, Fedir Yaremenko

Institutions: National Academy of Medical Sciences of Ukraine, State Institution "V. Danilevsky Institute for Endocrine Pathology Problems of NAMS of Ukraine"

Language: English

Topic: Estrogen and related hormone effects

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4299608919

FWCI:

Cites: 17

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Related to: 10