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Ethnic Stratification of the Association of RGS4 Variants with Antipsychotic Treatment Response in Schizophrenia

Year: 2020
Type: article
Abstract: Genetic association studies, including a large meta-analysis, report association of Regulator of G Protein Signaling 4 (RGS4) with schizophrenia in the context of heterogeneity. The central role of RGS4 in regulating signaling via Gi/o coupled neurotransmitter receptors led us to hypothesize that there may be RGS4 genotypes predictive of specific disease phenotypes and antipsychotic treatment responses.
DOI: 10.17615/tmas-ma60
Authors: Lieberman, Jeffrey, Campbell, Daniel B., Sullivan, Patrick F., Levitt, Pat, Ebert, Philip J., Stroup, T. Scott, Skelly, Tara
Language: English
Field: Medicine
Open Access status: green
Funders: Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, AstraZeneca, GlaxoSmithKline, Vanderbilt University, Vanderbilt Kennedy Center, Vanderbilt University Medical Center, National Institute of Mental Health
Awards: G1519962528, G3284271864, G4086995873, G5682974147, G6996713911, G8391480415, G8700482840
OpenAlex ID: W4299841335
FWCI:
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