Work

Extracellular Signals and Pancreatic β-cell Development: A Brief Review

Year: 2002

Type: article

Abstract: Cell lineage development is a finely tuned process of proliferation and differentiation, survival and apoptosis, that is regulated by numerous extracellular signals. Here we review some of the extracellular signals--including insoluble cell-cell and extracellular matrix-cell interactions, as well as soluble factors--that appear critical for pancreatic beta-cell development. Knowledge of how these signals control the development of pancreatic endocrine stem/precursor cells into fully functional insulin-secreting beta cells is a platform for the restoration of beta-cell function and the cure therapy of type 1 diabetes.

Source: Molecular Medicine

DOI: 10.1007/bf03402081

Authors: Fang-Xu Jiang, Leonard C. Harrison

Institutions: The Royal Melbourne Hospital, Walter and Eliza Hall Institute of Medical Research

Language: English

Topic: Pancreatic function and diabetes

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190