Work

Experimental medicinal hepatitis. Hepatoprotective eﬀects of the drug Laennec in models of toxic liver injury with paracetamol or alcohol

Year: 2022

Type: article

Abstract: Hepatoprotectors are necessary for the treatment of alcoholic and non-alcoholic (including medicinal) liver damage. This paper presents the results of a study of the Laennec hepatoprotector, produced on the basis of pharmaceutically standardized human placental hydrolysates (HPH). The use of HSP in toxic liver damage with alcohol or paracetamol led to a signiﬁcant decrease in markers of liver dysfunction (AST, ALT, bilirubin, MDA), which increase when the models are reproduced. The hepatoprotective eﬀect of Laennec was conﬁ rmed by the results of histological studies, indicating a reduction in inﬂ ammation and preservation of the liver parenchyma. Histological studies also indicated the nephroprotective and cardioprotective eﬀects of Laennec in liver damage with both alcohol and paracetamol.

Source: Экспериментальная и клиническая гастроэнтерология

DOI: 10.31146/1682-8658-ecg-199-3-86-92

Authors: O. A. Gromova, I. Yu. Torshin, V. I. Demidov, N. Yu. Zhidomorov, A. G. Kalacheva, T. E. Bogacheva, T. R. Grishina

Institutions: Russian Academy of Sciences, Federal Research Center “Computer Science and Control” of the Russian Academy of Sciences, Ivanovo State Medical Academy

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4302018455

FWCI: 0.579

Cites: 5

Cited by: 5

Related to: 10