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A study on green synthesis, characterization of chromium oxide nanoparticles and their enzyme inhibitory potential

Year: 2022

Type: article

Abstract: The conventional chemical methods of nanoparticles synthesis have been effectively replaced by nanoparticle synthesis mediated by plants. The current study describes the environmental friendly synthesis of chromium oxide nanoparticles (Cr 2 O 3 NPs) using Erythrophleum guineense plant extract. The synthesis of Cr 2 O 3 NPs was validated by UV/VIS spectroscopy, Energy Dispersive X-Ray (EDX), Scanning Electron Microscopy (SEM), and X-ray diffraction (XRD) studies. The appearance of the Sharpe peak at 460 nm in the UV/Vis spectrum and the colour change caused by surface plasma resonance confirmed the formation of Cr 2 O 3 NPs. The EDX spectrum of Cr 2 O 3 nanoparticles revealed the presence of carbon, oxygen, and chromium, while SEM analysis revealed an irregular round morphology (with a size below 400 nm). In addition, XRD studies suggested their crystalline nature by the characteristic peaks at 34° and 36° and 42° (2Ɵ), respectively. The green synthesized Cr 2 O 3 NPs showed promise as in-vitro cholinesterase inhibitor at tested concentrations (62.5–1,000 μg/ml), with IC 50 values of 120 and 100 μg/ml against Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE), respectively. The results suggested that the green synthesized Cr 2 O 3 NPs could be used in the future to stop enzyme from working and for other biological activities.

Source: Frontiers in Pharmacology

DOI: 10.3389/fphar.2022.1008182