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Cardiac Involvement and Absence of Asthma – What is Phenotype Specificity of EGPA: A Case Report

Year: 2022

Type: article

Abstract: Eosinophilic granulomatosis with polyangiitis (EGPA) typically is characterized by asthma, blood eosinophilia, and extrapulmonary manifestations.Asthma is a major EGPA symptom affecting almost all patients, but cardiac involvement is one of the most serious manifestations, responsible for 31% of deaths.Two recently defined phenotypes of EGPA, according to the patient's antineutrophil cytoplasmic antibody (ANCA) status, differ significantly in clinical features and prognosis.We share a case of EGPA characterized by atypical manifestation without any evidence of asthma, in whom extensive cardiac involvement was the dominant manifestation of vasculitis.This case demonstrates the difficulties associated with phenotyping EGPA and highlights the importance of cardiac magnetic resonance imaging (CMRI) in definitive diagnosis.

Source: Clinical Medicine & Research

DOI: 10.3121/cmr.2022.1683

Authors: Justyna Fijolek, Elzbieta Wiatr, Katarzyna Blasinska, Dorota Piotrowska-Kownacka, Kazimierz Roszkowski-Sliz

Institution: Central Clinical Hospital

Language: English

Topic: Vasculitis and related conditions

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4303457391