Work

Emerging Roles of the α-Catenin Family Member α-Catulin in Development, Homeostasis and Cancer Progression

Year: 2022

Type: review

Abstract: α-catulin, together with vinculin and the α-catenins, belongs to the vinculin family of proteins, best known for their actin-filament binding properties and crucial roles in cell-cell and cell-substrate adhesion. In the past few years, an array of binding partners for α-catulin have surfaced, which has shed new light on the possible functions of this protein. Despite all this information, the molecular basis of how α-catulin acts in cells and controls a wide variety of signals during morphogenesis, tissue homeostasis, and cancer progression remains elusive. This review aims to highlight recent discoveries on how α-catulin is involved in a broad range of diverse biological processes with an emphasis on cancer progression.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms231911962

Authors: Mateusz Gielata, Kamila Karpińska, Tomasz Pieczonka, Agnieszka Kobielak

Institution: University of Warsaw

Language: English

Topic: Cell Adhesion Molecules Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,408