Occupational heat exposure and prostate cancer risk: A pooled analysis of case-control studies
Year: 2022
Type: article
Abstract: BACKGROUND: Heat exposures occur in many occupations. Heat has been linked to key carcinogenic processes, however, evidence for associations with cancer risk is sparse. We examined potential associations between occupational heat exposure and prostate cancer risk in a multi-country study. METHODS: We analysed a large, pooled dataset of 3142 histologically confirmed prostate cancer cases and 3512 frequency-matched controls from three countries: Canada, France, and Spain. Three exposure indices: ever exposure, lifetime cumulative exposure and duration of exposure, were developed using the Finnish Job-Exposure Matrix, FINJEM, applied to the lifetime occupational history of participants. We estimated odds ratios (ORs) and 95% confidence intervals (CIs), using conditional logistic regression models stratified by 5-year age groups and study, adjusting for potential confounders. Potential interactions with exposure to other occupational agents were also explored. RESULTS: Overall, we found no association for ever occupational heat exposure (OR 0.97; 95% CI 0.87, 1.09), nor in the highest categories of lifetime cumulative exposure (OR 1.04; 95% CI 0.89, 1.23) or duration (OR 1.03; 95% CI 0.88, 1.22). When using only the Spanish case-control study and a Spanish Job Exposure Matrix (JEM), some weakly elevated ORs were observed. CONCLUSIONS: Findings from this study provide no clear evidence for an association between occupational heat exposure and prostate cancer risk.
Source: Environmental Research
Authors: Alice Hinchliffe, Juan Alguacil, Wendy Bijoux, Manolis Kogevinas, Florence Menegaux, Marie-Elise Parent, Beatriz Pérez Gomez, Sanni Uuksulainen, Michelle C. Turner
Institutions: Universitat Pompeu Fabra, Barcelona Institute for Global Health, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Universidad de Huelva, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Centre de recherche en Epidémiologie et Santé des Populations, Municipal Institute for Medical Research, Hospital del Mar Research Institute, Institut National de la Recherche Scientifique, Centre Armand-Frappier Santé Biotechnologie, Université de Montréal, Instituto de Salud Carlos III, Centro Nacional de Epidemiología, Finnish Institute of Occupational Health
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,550
Funders: Cancer Research Society, Ministère du Développement Économique, de l’Innovation et de l’Exportation, Fundación Bancaria Caja de Ahorros de Asturias, Ministerio de Ciencia, Innovación y Universidades, Eno Scientific Foundation, Canadian Cancer Society, European Commission, Fundación Científica Asociación Española Contra el Cáncer, Generalitat de Catalunya, Ligue Contre le Cancer, Fondation de France, Ministerio de Ciencia e Innovación, Universidad de Oviedo, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, Consejería de Educación, Junta de Castilla y León, Institut de Cardiologie de Montréal, Fundación Marqués de Valdecilla, Canadian Institutes of Health Research, Fonds de Recherche du Québec - Santé, Instituto de Salud Carlos III, Conselleria de Sanitat Universal i Salut Pública, European Social Fund
Awards: G1343860231, G1355068056, G1900157527, G1943266716, G2816224001, G2973101097, G3360488230, G3419946538, G3537113396, G3635063837, G3771020718, G3807906117, G4566175803, G4764183276, G5578384164, G5805666617, G5886078521, G6302472787, G7894819836, G794184282, G8158329446, G856234917, G8759146715
OpenAlex ID: W4306777656