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Morning SARS-CoV-2 Testing Yields Better Detection of Infection Due to Higher Viral Loads in Saliva and Nasal Swabs upon Waking

Year: 2022

Type: article

Abstract: Our findings suggest that collecting saliva and nasal swab specimens in the morning immediately after waking yields higher SARS-CoV-2 viral loads than collection later in the day. The higher viral loads from morning specimen collection are predicted to significantly improve detection of SARS-CoV-2 in symptomatic individuals, particularly when using moderate- to low-analytical-sensitivity COVID-19 diagnostic tests, such as rapid antigen tests.

Source: Microbiology Spectrum

DOI: 10.1128/spectrum.03873-22

Authors: Alexander Viloria Winnett, Michael K. Porter, Anna E. Romano, Emily S. Savela, Reid Akana, Natasha Shelby, Jessica A. Reyes, Noah W. Schlenker, Matthew M. Cooper, Alyssa M. Carter, Jenny Ji, Jacob T. Barlow, Colten Tognazzini, Matthew Feaster, Ying-Ying Goh, Rustem F. Ismagilov

Institutions: California Institute of Technology, Department of Public Health

Language: English

Topic: SARS-CoV-2 detection and testing

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

Funders: Bill and Melinda Gates Foundation, California Institute of Technology, National Institutes of Health, National Institute of General Medical Sciences, David Geffen School of Medicine, University of California, Los Angeles

Awards: California Institute of Technology - to characterize the virological features of a cohort of COVID-19 positive patients for improving diagnostic test deployment and understanding of tr..., UCLA-Caltech Medical Scientist Training Program, Predoctoral Biotechnology Leadership Training in Micro/Nanomedicine

OpenAlex ID: W4307302124

FWCI: 2.031

Cites: 39

Cited by: 19

Related to: 10