Work

Metabolite profiling of green algae Halimeda opuntia to target hepatitis C virus-796 polymerase inhibitors assisted by molecular docking

Year: 2022

Type: article

Abstract: Ethanol extracts of Caulerpa racemose, Halimeda opuntia, Padina pavonica, Polycladia myrica, and Turbinaria ornata were tested for anti-Hepatitis C virus activity. H. opuntia ethanol extract exhibited activity against hepatitis C virus (HCV) with IC50 value of 7.14 µg/mL. LCHR-ESI-MS metabolite profiling of H. opuntia ethanol extract characterized fifteen metabolites, which were screened for their polymerase inhibitory (HCV-796) binding sites based on molecular docking simulation. Interestingly 4,9-diacetoxtudoteal showed good interaction energies and formed significant interactions with the HCV-796 binding site.

Source: South African Journal of Botany

DOI: 10.1016/j.sajb.2022.10.038

Authors: Iman A.M. Abdel-Rahman, Eman Zekry Attia, Omar M. Aly, Hani Saber, Mohammed I. Rushdi, Usama Ramadan Abdelmohsen

Institutions: South Valley University, Minia University, Port Said University, Deraya University

Language: English

Topic: Seaweed-derived Bioactive Compounds

Subfield: Aquatic Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,750