Year: 2022
Type: article
Abstract: Ras-associated binding (Rab) GTPases control diverse stages of endo and exocytic pathways. Functional impairments of Rabs and its associated proteins have been implicated in many hereditary and neurological diseases. Although Rabs are not classically considered as oncoproteins, many Rabs have been involved in tumor progression/proliferation and its aggressiveness. Rabs contribute to tumor cell migration, invasion of cancer cell to extracellular matrix (ECM) and modification of tumor microenvironment through modulation in integrin trafficking, exosomal and protease secretions. In the present review, current knowledge about the pathogenesis and tumor progression of some Rabs (Rab27, 25 & 21) has been discussed.
DOI: 10.5772/dmht.09
Author: Tehreem Tahir
Institution: Institute of Biomedical and Genetic Engineering
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4307448271