Work

Discovery of orally active 1,4,5,6,8-pentaazaacenaphthylens as novel, selective, and potent covalent BTK inhibitors for the treatment of rheumatoid arthritis

Year: 2022

Type: article

Source: European Journal of Medicinal Chemistry

DOI: 10.1016/j.ejmech.2022.114940

Authors: Xiaobao Fang, Chunxiao Liu, Kun Zhang, Wanping Yang, Zewen Wu, Shige Shen, Yule Ma, Xun Lu, Yadong Chen, Tao Lu, Qinghua Hu, Yulei Jiang

Institutions: China Pharmaceutical University, State Key Laboratory of Natural Medicine

Language: English

Topic: Computational Drug Discovery Methods

Subfield: Computational Theory and Mathematics

Field: Computer Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, China Pharmaceutical University, Double First Class University Plan

Awards: G3404668988, G3511173994

OpenAlex ID: W4310071459

FWCI: 0.54

Cites: 36

Cited by: 4

Related to: 10