The design of experiments (DoE) in optimization of an aerobic flow Pd-catalyzed oxidation of alcohol towards an important aldehyde precursor in the synthesis of phosphatidylinositide 3-kinase inhibitor (CPL302415)
Year: 2022
Type: article
Abstract: inhibitor. Applying this environmental-friendly, sustainable catalytic oxidation we significantly increased product yield (up to 84%) and by eliminating of workup step, we improved the waste index and E factor (up to 0.13) in comparison with the stoichiometric synthesis. The process was optimized by using the DoE approach.
Source: RSC Advances
DOI: 10.1039/d2ra07003k
Institutions: Warsaw University of Technology, Celon Pharma (Poland)
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,042
Funder: Narodowe Centrum Badań i Rozwoju
Award: G7887796180
OpenAlex ID: W4311290179