Work

Design, synthesis and evaluation of 1-(1,5-bis(4-substituted phenyl)-2-methyl-1 H -pyrrol-3-yl)- N -methylmethanamines as SERT inhibitors with potential antidepressant action

Year: 2022

Type: article

Abstract: antidepressant activity using the unpredictable chronic mild stress (UCMS) protocol to induce depression in mice. The effect of BM212 and SA-5 on the behaviour of the animals was assessed and compared against the standard drug sertraline. SA-5 at 20 mg per kg body weight was found to have a statistically significant impact on the behaviour of depressed animals.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d2md00243d

Authors: Anjani Uma Rani Wunnava, Sony Priya Kurati, Kilari Eswar Kumar, Murali Krishna Kumar Muthyala

Institution: Andhra University

Language: English

Topic: Treatment of Major Depression

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Science for Equity, Empowerment and Development Division