Work

The Relationship between Serum Levels of Irisin and Gestational Diabetes

Year: 2022

Type: article

Abstract: Background: Hyperglycemia often occurs in pregnant women with a significant increase in the global prevalence of diabetes. This phenomenon provides a large amount of research data for studying the relationship between pregnancy and blood glucose. Irisin is a myokine first identified for its ability to induce the browning of white adipose tissue, to increase energy expenditure, and to protect against insulin resistance and obesity. Objectives: The aim is to assess the relationship between serum levels of irisin and gestational diabetes mellitus (GDM). Materials and Methods: A case–control study was conducted at the Department of Obstetrics and Gynecology at Al-Imamian Al-Kadhemain Medical City, from the first of January 2020 to the end of October 2020. Pregnant women at the second trimester ( n = 100) were divided into two groups: women with GDM previously diagnosed as case group ( n = 50) and healthy pregnant women as control group ( n = 50). Results: Mean serum level of irisin for the case group was 707.5 ± 167.2 ng/mL, and 892 ± 123.8 ng/mL for the control group, with a highly significant decrease in the case group than that in the control group ( P < 0.001). The validity test of the serum irisin level at cutoff value of 702 shows that sensitivity was 94%, specificity was 90%, negative predicted value was 94%, positive predicted value was 90%, and the accuracy of the test was 92%. Conclusion: Serum levels of irisin were significantly lower in patients with GDM.

Source: Medical Journal of Babylon

DOI: 10.4103/mjbl.mjbl_52_22

Authors: Jenan Abd Al Jasem, Hala Abd Al-Qadir Al-Moayad

Institution: Nahrain University

Language: English

Topic: Gestational Diabetes Research and Management

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $200