The association of functional brain networks common to source monitoring with the symptoms of schizophrenia
Year: 2022
Type: article
Study design: Observational Study
Abstract: was conducted to analyze group differences.Results: A significant group by age interaction, was found in PFC glutamate (beta ¼ 0.01, SE ¼ 0.01, t ¼ -2.69, p ¼ 0.009) and Glx (beta ¼ -0.012, SE ¼ 0.01, t ¼ -2.412, p ¼ 0.017), whereby glutamate and Glx levels showed a more pronounced age-related decrease in FPE compared to HR (glutamate: beta ¼ 0.022, SE ¼ 0.01, t ¼ 2.695, p ¼ 0.021; Glx: beta ¼ 0.030, SE ¼ 0.01, t ¼ 2.599, p ¼ 0.027) and controls (beta ¼ 0.02, SE ¼ 0.01, t ¼ 2.654, p ¼ 0.023; Glx: beta ¼ 0.027, SE ¼ 0.01, t ¼ 2.555, p ¼ 0.030).There was a also a significant effect of group, but not of age nor sex, for GPC+PCh levels in the PFC (beta ¼ 0.01, SE ¼ 0.005, t ¼ 5.408 p ¼ 0.006), whereby GPC+PCh levels were higher in FPE (beta ¼ -0.01, SE ¼ 0.01, t ¼ -3.140, p ¼ 0.006) compared to controls.There were no significant group effects in the medial temporal lobe.Discussion: These results are consistent with previous studies suggesting that changes in glutamatergic neurotransmission in the prefrontal cortex according to age and illness stage may be involved in the pathophysiology of psychotic disorders [1,2,3].Likewise, finding increasing levels of neuroinflammation markers (GPC+PCh) [4] with age in patients with FPE adds to previous evidence supporting the role of inflammatory processes in the early stages of psychosis [5].
Source: Neuroscience Applied
Authors: S. Eickhoff, S. Borgwardt, T. Woodward
Institutions: University of Lübeck, University of British Columbia
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,000
OpenAlex ID: W4313200823