Aşılı ve Aşısız Sağlık Çalışanlarında SARS-CoV-2 Enfeksiyonları: CoronaVac'ın Etkinliğinin Değerlendirilmesi
Year: 2022
Type: article
Study design: Observational Study
Abstract: Although several vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been efficient against clinically significant coronavirus disease 2019 (COVID-19), breakthrough infections are being reported for several months. Here we conducted a prospective cohort study to assess the effectiveness of an inactive vaccine (CoronaVac; Sinovac, China) against SARS-CoV-2 by following cases of COVID-19 among vaccinated health care workers. Between March and September 2021, 1012 vaccinated and 211 unvaccinated healthcare workers from a tertiary care university hospital were followed for PCR-confirmed SARS-CoV-2 infections. COVID-19 active surveillance of the healthcare workers was carried out by the Infection Prevention and Control Unit of the institution. Anti-spike antibody values before and after COVID-19 were recorded. During a six-month follow-up program, in 35 out of 1012 (3.5%) fully vaccinated and in 16 out of 211 (7.6%) unvaccinated healthcare workers SARS-CoV-2 infections were documented. There was a statistically significant difference between vaccinated vs. unvaccinated workers regarding SARS-CoV-2 infections (P=0.003). Although all unvaccinated healthcare workers experienced symptomatic COVID-19, the vaccinated group suffered less from symptoms (100% vs. 77.1%, respectively; P=0.045). CoronaVac was 64.5% and 88.4% effective in preventing symptomatic and severe disease, respectively, and had an efficacy of 100% in preventing death among healthcare workers.In accordance with our findings, it was seen that CoronaVac could not prevent breakthrough infections, but was highly effective in preventing severe disease and death in healthcare workers for a period of six months after two consecutive doses.
Authors: Demirbakan, Hadiye, Koçer, İpek, Bayram, Ayşen
Institution: Sanko University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4313355441