An efficient, concise, and scalable synthesis of Izenamide A and B via asymmetric reduction of γ-amino β-keto ester using 2-methyl-CBS-oxazaborolidine catalysts
Year: 2022
Type: article
Abstract: A efficient and concise synthesis of izenamides A and B is reported. We have followed a more convergent approach while avoiding costly and harmful chemicals. Major attraction of this synthesis is the first ever report of highly asymmetric reduction of N-Boc γ-amino β-ketoester using 2-Methyl-CBS-oxazaborolidine catalysts to generate the key intermediate. Further, this reaction can be of immense significance as γ-amino β-ketoesters constitutes an important motif in drug discovery.
Source: Results in Chemistry
Institution: Andhra University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,000
OpenAlex ID: W4313367366