Year: 2022
Type: review
Abstract: Direct delivery to the lung via inhalation is arguably one of the most logical approaches to treat lung cancer using drugs. However, despite significant efforts and investment in this area, this strategy has not progressed in clinical trials. Imaging drug delivery is a powerful tool to understand and develop novel drug delivery strategies. In this review we focus on imaging studies of drug delivery by the inhalation route, to provide a broad overview of the field to date and attempt to better understand the complexities of this route of administration and the significant barriers that it faces, as well as its advantages. We start with a discussion of the specific challenges for drug delivery to the lung via inhalation. We focus on the barriers that have prevented progress of this approach in oncology, as well as the most recent developments in this area. This is followed by a comprehensive overview of the different imaging modalities that are relevant to lung drug delivery, including nuclear imaging, X-ray imaging, magnetic resonance imaging, optical imaging and mass spectrometry imaging. For each of these modalities, examples from the literature where these techniques have been explored are provided. Finally the different applications of these technologies in oncology are discussed, focusing separately on small molecules and nanomedicines. We hope that this comprehensive review will be informative to the field and will guide the future preclinical and clinical development of this promising drug delivery strategy to maximise its therapeutic potential.
Source: Advanced Drug Delivery Reviews
Institution: King's College London
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,150
Funders: AstraZeneca, King’s College London, Wellcome Trust, Cancer Research UK, National Institute for Health and Care Research, Imperial College London, King's College London, GE Healthcare, Medical Research Council, Engineering and Physical Sciences Research Council, Guy's and St Thomas' NHS Foundation Trust, Research England, Centre For Medical Engineering, King’s College London
Awards: G1054121244, G1211483440, G1247657515, King's College London Medical Engineering Centre of Research Excellence, G1481929885, G182908367, G1990606676, G2119833926, G2417159676, G2869883816, G2870969529, G3063922784, G353743561, G4198588280, EPSRC Centre for Doctoral Training in Smart Medical Imaging at King's College London and Imperial College London, G508714220, G5296857752, G5893523844, King's College London Medical Engineering Centre of Research Excellence, G5935007269, A multiuser radioanalytical facility for molecular imaging and radionuclide therapy research, G6206044308, Next generation molecular imaging and therapy with radionuclides, G6686586965, G6868811358, G7955567073, G8058084215, G8298313232, G8303168876, G8775246936, G938335843, G961285871
OpenAlex ID: W4313435406