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Macrophage-Regulating Drug Treatment Promotes Tissue Proliferation in a Diabetic Foot Ulcer Patient with Exposed Anterior Tibialis Tendon - A Case Report

Year: 2022

Type: article

Abstract: A 53-year-old woman with type 2 diabetes mellitus (DM), peripheral arterial disease (PAD), hypertension, and hyperlipidemia was sent to the emergency department with exposed tendon and soft tissue necrosis from a diabetic foot ulcer (DFU).After 10 days of treatment with broad-spectrum antibiotics and angioplasty, tissue proliferation was still halted by persistent inflammation.Despite multiple interventions, the wound did not heal.Therefore, the topical macrophage-modulating drug, ON101, was used twice daily.The ulcer area then completely closed after 16 weeks.In our study, macrophage modulation can be a new approach to promote tissue repair and rescue difficult wounds.

Source: Annals of Case Reports

DOI: 10.29011/2574-7754.101102

Authors: Yun-Nan Lin, Jui-Ching Chen, Kuan-I Lee, Shyi-Gen Chen, Yur-Ren Kuo

Institutions: Kaohsiung Medical University, Kaohsiung Medical University Chung-Ho Memorial Hospital, Oneness Biotech Co., Ltd. (Taiwan)

Language: English

Topic: Wound Healing and Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4313656136