Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia
Year: 2023
Type: article
Abstract: BACKGROUND: After a strong epidemiological link to diet was established in an outbreak of pancytopenia in cats in spring 2021 in the United Kingdom, 3 dry diets were recalled. Concentrations of the hemato- and myelotoxic mycotoxins T-2, HT-2 and diacetoxyscirpenol (DAS) greater than the European Commission guidance for dry cat foods were detected in the recalled diets. OBJECTIVES: To describe clinical and clinicopathological findings in cats diagnosed with suspected diet induced pancytopenia. ANIMALS: Fifty cats presenting with pancytopenia after exposure to a recalled diet. METHODS: Multicenter retrospective case series study. Cats with known exposure to 1 of the recalled diets were included if presented with bi- or pancytopenia and underwent bone marrow examination. RESULTS: Case fatality rate was 78%. Bone marrow aspirates and biopsy examination results were available in 23 cats; 19 cats had a bone marrow aspirate, and 8 cats had a biopsy core, available for examination. Bone marrow hypo to aplasia-often affecting all cell lines-was the main feature in all 31 available core specimens. A disproportionately pronounced effect on myeloid and megakaryocytic cells was observed in 19 cats. Myelofibrosis or bone marrow necrosis was not a feature. CONCLUSION AND CLINICAL IMPORTANCE: Mycotoxin induced pancytopenia should be considered as differential diagnosis in otherwise healthy cats presenting with bi- or pancytopenia and bone marrow hypo- to aplasia.
DOI: 10.1111/jvim.16613
Authors: Barbara Glanemann, Karen Humm, Mariana Abreu, Sophie Aspinall, David Buckeridge, Hope Carveth, Hannah Darcy, Jessica Florey, Polly Frowde, Isuru Gajanayake, Kate Green, Emma Holmes, Alenka Hrovat, Anne-Katherine Jasensky, Bryn A. Jones, Vasiliki Lantzaki, Eve JY Lo, Kirsty MacDonald, Kevin O'Brien, Alejandro Suárez-Bonnet, Nele Van den Steen, Balazs Szladovits, Annelies Willems, Helen Wilson
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,000
OpenAlex ID: W4313656254