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The clinical and genomic distinctions of Class1/2/3 BRAF-mutant colorectal cancer and differential prognoses

Year: 2023
Type: article
Study design: Observational Study
Abstract: BRAF mutations are the oncogenic drivers in colorectal cancer and V600 mutations (Class1), which lead to RAS-independent active monomers, are the most common mutation types. BRAF non-V600 mutants can be further classified as RAS-independent active dimers (Class2) and RAS-dependent impaired kinase (Class3). We retrospectively reviewed the mutational profiles of 328 treatment-naïve colorectal tumors with BRAF mutations detected using capture-based hybrid next-generation sequencing targeting 400 + cancer-related genes. The clinical and genetic distinctions of patients harboring Class1/2/3 BRAF mutations were investigated, which revealed that tumors with Class1 BRAF mutations showed more unique genomic profiles than those with Class2/3 mutations. Also, by using an external dataset from cBioPortal, we demonstrated that patients with Class3 BRAF mutations had the best survival outcomes compared to the other two subgroups. These findings promoted the development of anti-BRAF strategies by distinguishing BRAF mutant subgroups.
DOI: 10.1186/s40364-022-00443-8
Authors: Yungchang Chen, Hao Sun, Yanhong Deng, Yutong Ma, He Huang, Yang Liu, Yaru Zhang, Hongyu Zhang, Sheng Ye, Mingyan E, Hongqiang Guo, Mengmeng Wu, Chunman Wu, Xingxiang Pu, Xinggui Chen, Chaoyong Liang, Qiuxiang Ou, Huawei Weng, Xue Wu, Yang Shao, Anxin Gu, Tongyu Lin
Institutions: University of Electronic Science and Technology of China, Sichuan Cancer Hospital, Chongqing University, Chongqing Cancer Hospital, Sixth Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Fifth Affiliated Hospital of Sun Yat-sen University, The First Affiliated Hospital, Sun Yat-sen University, Harbin Medical University, Third Affiliated Hospital of Harbin Medical University, Zhengzhou University, Henan Cancer Hospital, Central South University, Hunan Cancer Hospital, Guangdong Medical College, Guangxi Medical University, Tumor Hospital of Guangxi Medical University, Nanjing Medical University
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,390
OpenAlex ID: W4317876277
FWCI: 2.229
Cites: 10
Cited by: 18
Related to: 10