Work

Glycation of LDL: AGEs, impact on lipoprotein function, and involvement in atherosclerosis

Year: 2023

Type: review

Abstract: Atherosclerosis is a complex disease, and there are many factors that influence its development and the course of the disease. A deep understanding of the pathological mechanisms underlying atherogenesis is needed to develop optimal therapeutic strategies and treatments. In this review, we have focused on low density lipoproteins. According to multiple studies, their atherogenic properties are associated with multiple modifications of lipid particles. One of these modifications is Glycation. We considered aspects related to the formation of modified particles, as well as the influence of modification on their functioning. We paid special attention to atherogenicity and the role of glycated low-density lipoprotein (LDL) in atherosclerosis.

Source: Frontiers in Cardiovascular Medicine

DOI: 10.3389/fcvm.2023.1094188

Authors: Anastasia V. Poznyak, Vasily N. Sukhorukov, Raisa Surkova, Nikolay A. Orekhov, Alexander N. Orekhov

Institutions: Institute for Atherosclerosis Research, Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences

Language: English

Topic: Advanced Glycation End Products research

Subfield: Clinical Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,295