Year: 2023
Type: article
Abstract: Measures of cardiovascular health (CVH) assessed by a combination of behavioral and biological factors has shown protective associations with all-cause mortality. The mechanisms underlying these associations have not been fully elucidated. In this study, we characterized the plasma proteomics profile of CVH and tested whether specific proteins mediated the associations between CVH and all-cause mortality in participants of the InCHIANTI study. Of the 1301 proteins tested, 92 proteins were associated with CVH (22 positively, 70 negatively). Proteins most strongly associated with CVH included leptin (LEP), fatty acid binding protein 3 (FABP3), Angiopoietin-2 (ANGPT2), and growth-differential factor 15 (GDF15). Of the 92 CVH-associated proteins, 33 proteins significantly mediated the associations between CVH and all-cause mortality, with percent mediation ranging from 5 to 30%. The most significant mediating proteins were GDF15 and insulin-like growth factor 2 (IGFBP2). Proteins associated with better CVH were enriched for proteins that reflect the suppression of the complement coagulation and GH/IGF pathways.
Source: Nutrients
DOI: 10.3390/nu15030781
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,892
Awards: G1090328858, G1248102086, G1789381357, G2243371366, G2495888254, G259853090, G2857511458, G3117239229, G3303013554, G3362311673, G374919288, G4109153585, G4507648799, G4652745033, Associations between ideal cardiovascular health, frailty & age related declines, G4940211717, G5038676132, G6145130349, G7333524540, HISPANIC SECONDARY STROKE PREVENTION INITIATIVE, G93682057
OpenAlex ID: W4319083529