Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease
Year: 2023
Type: article
Study design: Observational Study
Abstract: Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 ± 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 ± 8.73 vs. 62.8 ± 9.24; p = 0.297) or in the time from symptoms onset (5.66 ± 4.65 vs. 5.21 ± 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.
Source: Journal of Clinical Medicine
DOI: 10.3390/jcm12041329
Authors: Diego Santos-García, Ariadna Laguna, Jorge Hernández-Vara, Teresa de Deus Fonticoba, Carlos Cores Bartolomé, Maria J. Feal Painceiras, Maria Cristina Íñiguez-Alvarado, Iago García Díaz, Silvia Jesús, Maria Teresa Boungiorno, Lluís Planellas, Marina Cosgaya, Juan García Caldentey, Nuria Caballol, Ines Legarda, Iria Cabo, Lydia López Manzanares, Isabel González Aramburu, Maria A. Ávila Rivera, Víctor Gómez Mayordomo, Víctor Nogueira, Víctor Puente, Julio Dotor García-Soto, Carmen Borrué, Berta Solano Vila, María Álvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martínez Castrillo, Pilar Sánchez Alonso, Maria G. Alonso Losada, Nuria López Ariztegui, Itziar Gastón, Jaime Kulisevsky, Manuel Menéndez González, Manuel Seijo, Javier Rúiz Martínez, Caridad Valero, Mónica Kurtis, Jessica González Ardura, Ruben Alonso Redondo, Carlos Ordás, Luis M. López Díaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir, on behalf of the COPPADIS Study Group
Institutions: Complexo Hospitalario Universitario A Coruña, Biomedical Research Networking Center on Neurodegenerative Diseases, Vall d'Hebron Institut de Recerca, Complejo Hospitalario Universitario de Ferrol, Consejo Superior de Investigaciones Científicas, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, University Hospital Mútua de Terrassa, Hospital Clínic de Barcelona, Hospital de Sant Joan Despí Moisès Broggi, Hospital Universitario Son Espases, Complejo Hospitalario de Pontevedra, Hospital Universitario de La Princesa, Marqués de Valdecilla University Hospital, Hospital Clínico San Carlos, Hospital Del Mar, Hospital Universitario Virgen Macarena, Hospital Universitario Infanta Sofía, Institut Català de la Salut, Institut d'Assistència Sanitària, Hospital General Universitario de Elche, Hospital Universitario Fundación Alcorcón, Hospital Universitari de Tortosa Verge de la Cinta, Hospital Universitario de Burgos, Hospital Universitario de Canarias, Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón y Cajal, Hospital Universitario Puerta de Hierro Majadahonda, University Hospital Complex Of Vigo, Complejo Hospitalario Universitario de Toledo, Complejo Hospitalario de Navarra, Hospital de Sant Pau, Hospital Universitario Central de Asturias, Donostiako Unibertsitate Ospitalea, Hospital Arnau de Vilanova, Hospital Ruber Internacional, Hospital Universitario De Cabueñes, Hospital Universitario Lucus Augusti, University of Maryland, Baltimore
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,892
OpenAlex ID: W4319600100