Disease severity in hospitalized COVID-19 patients: comparing routine surveillance with cohort data from the LEOSS study in 2020 in Germany
Year: 2023
Type: article
Abstract: INTRODUCTION: Studies investigating risk factors for severe COVID-19 often lack information on the representativeness of the study population. Here, we investigate factors associated with severe COVID-19 and compare the representativeness of the dataset to the general population. METHODS: We used data from the Lean European Open Survey on SARS-CoV-2 infected patients (LEOSS) of hospitalized COVID-19 patients diagnosed in 2020 in Germany to identify associated factors for severe COVID-19, defined as progressing to a critical disease stage or death. To assess the representativeness, we compared the LEOSS cohort to cases of hospitalized patients in the German statutory notification data of the same time period. Descriptive methods and Poisson regression models were used. RESULTS: Overall, 6672 hospitalized patients from LEOSS and 132,943 hospitalized cases from the German statutory notification data were included. In LEOSS, patients above 76 years were less likely represented (34.3% vs. 44.1%). Moreover, mortality was lower (14.3% vs. 21.5%) especially among age groups above 66 years. Factors associated with a severe COVID-19 disease course in LEOSS included increasing age, male sex (adjusted risk ratio (aRR) 1.69, 95% confidence interval (CI) 1.53-1.86), prior stem cell transplantation (aRR 2.27, 95% CI 1.53-3.38), and an elevated C-reactive protein at day of diagnosis (aRR 2.30, 95% CI 2.03-2.62). CONCLUSION: We identified a broad range of factors associated with severe COVID-19 progression. However, the results may be less applicable for persons above 66 years since they experienced lower mortality in the LEOSS dataset compared to the statutory notification data.
Source: BMC Infectious Diseases
Authors: Uwe Koppe, Julia Schilling, Melanie Stecher, Maria Madeleine Rüthrich, Adine Marquis, Michaela Diercke, Martina Haselberger, Carolin E. M. Koll, Michaela Niebank, Bettina Ruehe, Stefan Borgmann, Linus Grabenhenrich, Kerstin Hellwig, Lisa Pilgram, Christoph D. Spinner, Thomas Paerisch, the LEOSS study group, Christoph D. Spinner, Maria Madeleine Rüthrich, Julia Lanznaster, Stefan Borgmann, Kerstin Hellwig, Maria Vehreschild, Christian Hohmann, Frank Hanses, Kai Wille, Bjoern-Erik Jensen, Martin Hower, Siegbert Rieg, Juergen vom Dahl, Jan Rupp, Christoph Roemmele, Nora Isberner, Katja Rothfuss, Lukas Eberwein, Norma Jung, Timm Westhoff, Sebastian Dolff, Richard Strauss, Ingo Voigt, Michael von Bergwelt-Baildon, Uta Merle, Christian Degenhardt, Gernot Beutel, Lorenz Walter, Siri Göpel, Beate Gruener, Dominic Rauschning, Janina Trauth, Milena Milovanovic, Katja de With, Philipp Markart, Jessica Rueddel, Anette Friedrichs, Jan Kielstein, Lukas Tometten, David Heigener, Lars Wojtecki, Joerg Schubert, Wolfgang Guggemos, Stefani Roeseler, Mark Neufang
Institutions: Robert Koch Institute, University of Cologne, German Center for Infection Research, University Hospital Cologne, Jena University Hospital, Klinikum Passau, Klinikum Ingolstadt, St. Josef-Hospital, Ruhr University Bochum, Goethe University Frankfurt, Charité – Universitätsmedizin Berlin, TUM Klinikum, Technical University of Munich, Johannes Wesling Klinikum Minden, Düsseldorf University Hospital, Witten/Herdecke University, Klinikum Dortmund, University Medical Center Freiburg, Kliniken Maria Hilf, University Hospital Schleswig-Holstein, University of Lübeck, University Hospital Augsburg, Universitätsklinikum Würzburg, Robert Bosch Hospital, Klinikum Leverkusen, Universitätsklinik Marien Hospital Herne, Essen University Hospital, Universitätsklinikum Erlangen, Elisabeth-Krankenhaus Essen, LMU Klinikum, Ludwig-Maximilians-Universität München, University Hospital Heidelberg, Städtisches Klinikum Karlsruhe, Medizinische Hochschule Hannover, Krankenhaus St. Joseph-Stift Dresden, Universitätsklinikum Tübingen, University Hospital Ulm, Bundeswehrzentralkrankenhaus Koblenz, Bundeswehr, Universitätsklinikum Gießen und Marburg, University Hospital Carl Gustav Carus, Klinikum Fulda, Sophien-und Hufeland Klinikum, Klinikum Braunschweig, Klinikum Ernst von Bergmann, Agaplesion Diakonieklinikum Rotenburg, Elblandklinikum Riesa, München Klinik
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W4319973522