In Situ Gel with Silver Nanoparticles Prepared Using Agrimonia eupatoria L. Shows Antibacterial Activity

Year: 2023

Type: article

Abstract: Silver nanoparticles (Ag NPs) with antibacterial activity can be prepared in different ways. In our case, we used ecological green synthesis with Agrimonia eupatoria L. The plant extract was used with Ag NPs for the first time to prepare termosensitive in situ gels (ISGs). Such gels are used to heal human or animal skin and mucous membranes, as they can change from a liquid to solid state after application. Ag NPs were characterized with various techniques (FTIR, TEM, size distribution, zeta potential) and their antibacterial activity was tested against Staphylococcus aureus and Escherichia coli. In accordance with the TEM data, we prepared monodispersed spherical Ag NPs with an average size of about 20 nm. Organic active compounds from Agrimonia eupatoria L. were found on their surfaces using FTIR spectroscopy. Surprisingly, only the in situ gel with Ag NPs showed antibacterial activity against Escherichia coli, while Ag NPs alone did not. Ag NPs prepared via green synthesis using plants with medicinal properties and incorporated into ISGs have great potential for wound healing due to the antibacterial activity of Ag NPs and the dermatological activity of organic substances from plants.

Source: Life

DOI: 10.3390/life13020573

Authors: Ľudmila Balážová, Tomáš Wolaschka, Simona Rohaľová, Nina Daneu, Martin Stahorský, Aneta Salayová, Ľudmila Tkáčiková, Jarmila Eftimová

Institutions: University of Veterinary Medicine in Košice, Masaryk University, Jožef Stefan Institute, Jožef Stefan International Postgraduate School, Slovak Academy of Sciences, Institute of Geotechnics of the Slovak Academy of Sciences

Language: English

Topic: Nanoparticles: synthesis and applications

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,002

Funders: Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky, Agentúra na Podporu Výskumu a Vývoja, Vedecká Grantová Agentúra MŠVVaŠ SR a SAV

OpenAlex ID: W4321372829