Assessment of Serum Leptin Level and Insulin Resistance in Obese Subjects
Year: 2012
Type: article
Study design: Observational Study
Abstract: Background: To determine the relationship betweenserum leptin and insulin resistance in obese Pakistanisubjects.Methods: In this observational study fifty healthyobese and overweight subjects were selected by nonprobabilityconvenience sampling. Age, sex, height,weight and body mass index (BMI) of subjects wererecorded. Fasting plasma glucose, serum leptin andinsulin were measured. Fifty healthy non-obese subjectsserved as control group.Results: Serum leptin concentration was higher inobese subjects (52.8 ± 24.6 ng/ml), with p value 0.001 thanin non-obese healthy controls (6.3 ± 3.1 ng/ml). Serumleptin level was found higher in women (64.4ng/ml) thanin men (40.4ng/ml) only in obese group. Insulin resistancewas higher in obese subjects (11.1 ± 5.1), with p value 0.001than control group (0.9 ± 0.4). BMI strongly correlated withleptin concentration (r = 0.59 & p = 0.001) and insulinresistance (r = 0.372 & p = 0.001) in obese group. There washighly significant correlation between serum leptinconcentration and insulin resistance (r = 0.451 & p = 0.001)in this group. In the control group, there was nocorrelation between serum leptin concentration andinsulin resistance (r = 0.166 & p = 0.249).Conclusions: Serum leptin is positively correlatedwith insulin resistance in obese subjects. Serum leptinlevel and insulin resistance are higher in obese subjects
Author: Ahsan Kazmi
Institution: Rawalpindi Medical University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $35
OpenAlex ID: W4323920573