Work

Continuous‐Flow Enantioselective 1,4‐Addition Reactions of Malonates with Nitroolefins on Ni‐Supported Mesoporous Silica Materials with Co‐feeding of a Chiral Ligand

Year: 2023

Type: article

Abstract: A catalytic system is described in which achiral Ni is immobilized on mesoporous silica material with external addition of a chiral modifier enabling continuous‐flow enantioselective reactions with catalyst‐packed bed reactors. Continuous‐flow enantioselective 1,4‐addition reactions of dimethyl malonate with nitroalkenes proceeded with co‐feeding of a chiral diamine ligand, and the corresponding products were obtained in high yields with high enantioselectivities for more than 80 h with a turnover frequency of 3.1 h−1 based on [Ni].

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.202300024

Authors: Haruro Ishitani, Kan Kanai, Shū Kobayashi

Institution: The University of Tokyo

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,220

Funders: Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science