Reliability of LDL cholesterol estimation (Friedewald, Martin) is not affected by the thyroid metabolism
Year: 2019
Type: article
Study design: Observational Study
Abstract: Objective: The main purpose of the study is to determine whether hypothyroidism and/or hyperthyroidism has any significant effect on the reliability of the LDL-cholesterol (LDL-C) estimation by the Friedewald and the Martin equation. Design: Comparative Study Material and Methods: 40 patients with newly diagnosed autoimmune hypothyroidism (36 female, 4 male). Comparison of the deviations of the LDL-C assessments by the Friedewald and the Martin equation in a group of non-treated patients in an euthyreotic state. Results: The deviations in the LDL-C levels estimated by Friedewald or by Martin showed a non-systematic character. The differences in reliability from the measured LDL-C between the individual groups can be explained with the well-known variability of the LDL-C estimation by Friedewald in dependence on the TAG and TC levels. The LDL-C level estimations calculated by the Martin equation were higher than the estimations calculated by Friedewald in 6 instances, in one instance the values were identical. Conclusion: Systematic effect on the reliability of LDL-Cholesterol estimated either by the Friedewald or the Martin equation by the hyper- or hypofunction of the thyroid gland was not discovered.
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4360106596