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Supplementary Figures from DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair

Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figures. Sup. Fig. 1: Recuirtment of XRCC1 to stalled DNA replication forks is prevented by CtIP. Sup. Fig. 2: CK2 actiivty is required for stabilization of XRCC1 protein and its recuirtment to stalled forks. Sup. Fig. 3: Interaction of XRCC1 and DNA-PKcs complex is not essential for recruitment of phosphorylated DNA-PKcs foci to stalled forks. Sup. Fig. 4: DNA-PKcs is phosphorylated and recruited to sites of stalled replication forks. Sup. Fig. 5: Roles of DNA-PKcs in the recovery of replication stress-induced damage. Sup. Fig. 6: DNA-PKcs recruits XRCC1 to stalled replication forks.
DOI: 10.1158/0008-5472.22411761.v1
Authors: Songmin Ying, Zhihui Chen, Annette L. Medhurst, Jessica A. Neal, Zhengqiang Bao, Oliver Mortusewicz, Joanna McGouran, Xinming Song, Huahao Shen, Freddie C. Hamdy, Benedikt M. Kessler, Katheryn Meek, Thomas Helleday
Language: English
Open Access status: gold
OpenAlex ID: W4361877136
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