Supplementary Figure 1 from γ-H2AX Foci Formation as a Pharmacodynamic Marker of DNA Damage Produced by DNA Cross-Linking Agents: Results from 2 Phase I Clinical Trials of SJG-136 (SG2000)
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 105K, Measurement of γ-H2AX foci in lymphocytes (A) and xenograft tumor cells (B) following treatment of mice i.v. with either 0.15 or 0.3 mg/kg SJG-136. Samples were obtained at 2 and 24 hours and processed as described in materials and methods. Data are expressed as the % of cells which contain 0, 0-5, 5-10, 10-15, 15-20 or >20 foci.
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361908379